RLX G-quadruplex structure models presented by software Chimera [41].

(A) Top view (B) side view. (The purple balls stand for potassium ions). The docked results of berberine with RLX G-quadruplex presented by software PMV [42] (C) end stacking (D) groove binding. (Berberine was shown as stick model while the G-quadruplex as molecular surface model).