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Protocol for administering antibiotics by gavage ensures mice health.
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posted on 2013-02-20, 19:43 authored by Dag Henrik Reikvam, Alexander Erofeev, Anders Sandvik, Vedrana Grcic, Frode Lars Jahnsen, Peter Gaustad, Kathy D. McCoy, Andrew J. Macpherson, Leonardo A. Meza-Zepeda, Finn-Eirik Johansen(A) Sketch of protocol for gavage administration of vancomycin 50 mg/kg (V), neomycin 100 mg/kg (N), metronidazol 100 mg/kg (M), and amphotericin-B 1 mg/kg (Amf-B) every 12 hours with ampicillin 1 g/l ad libitum in drinking water (A). (B) Body weight, presented as percent of base line ( = Day 0), of mice successfully depleted of cultivable fecal microbiota by gavage (VNMAmf-B+A) or gavaged with water in equivalent volume and frequency (Sham). Control mice received water ad libitum only
