Protection from the toxic effects of the xenobiotic RPW-24 requires MDT-15, but not PMK-1.

<p>(A) The thirteen xenobiotic detoxification genes that were induced 4-fold or greater by RPW-24 in the NanoString nCounter gene expression analysis are presented. The top panel compares the RPW-24-mediated induction of these genes in vector control (L4440) and <i>mdt-15(RNAi)</i> animals, and the bottom panel shows these data for wild-type N2 versus <i>pmk-1(km25)</i> animals, as described in the legend for <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004143#ppat-1004143-g002" target="_blank">Figure 2</a>. * <i>p</i><0.05 for the comparison of the RPW-24-induced conditions. (B) Vector control (L4440), <i>mdt-15(RNAi)</i> and <i>pmk-1(RNAi)</i> animals were exposed to 70 µM RPW-24 or the solvent control DMSO from the L1 stage and photographed after 70 hours of development at 20°C. See <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004143#ppat.1004143.s004" target="_blank">Figure S4</a> for the quantification data from this experiment.</p>