Figure_9.tif (132.83 kB)
Proposed model of the inhibitory effects of CO upon STAT3 activation.
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posted on 2014-07-29, 03:15 authored by Yan-Chang Yang, Yu-Ting Huang, Chia-Wen Hsieh, Po-Min Yang, Being-Sun WungNO and CO have long been known to increase ROS via the inhibition of cytochrome c oxidase function by competing with oxygen binding. The increased intracellular low levels oxidative stress induces protein S-glutathionylation to prevent STAT3 nuclear translocation under inflammatory cytokine treatment. See the “Discussion" section for details.
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anatomybiological tissueepitheliumEpithelial cellsEndothelial cellsCardiovascular anatomycell biologyCell processesCellular stress responsesSignal transductioncell signalingSignaling cascadesStress signaling cascadeRedox signalingSTAT signalingMechanisms of signal transductionCellular typesMolecular cell biologycardiologyCardiovascular pharmacologyinhibitorycostat3
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