Proposed model of the inhibitory effects of CO upon STAT3 activation.

<p>NO and CO have long been known to increase ROS via the inhibition of cytochrome <i>c</i> oxidase function by competing with oxygen binding. The increased intracellular low levels oxidative stress induces protein S-glutathionylation to prevent STAT3 nuclear translocation under inflammatory cytokine treatment. See the “<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100677#s4" target="_blank">Discussion</a>" section for details.</p>