Proposed model of the inhibitory effects of CO upon STAT3 activation.

<p>NO and CO have long been known to increase ROS via the inhibition of cytochrome <i>c</i> oxidase function by competing with oxygen binding. The increased intracellular low levels oxidative stress induces protein S-glutathionylation to prevent STAT3 nuclear translocation under inflammatory cytokine treatment. See the “<a href="" target="_blank">Discussion</a>" section for details.</p>