Projected number of newborns with SCA born in 2010 and 2050 for the three most affected countries (Nigeria, India, and the DRC), WHO regions, HbS regions, and worldwide.

Complete data for all countries are presented in Table S1. Proportions per category are indicated for the predicted newborns with SCA. Relative changes are shown within parentheses.

a

Calculated as the product between the median SCA frequency based on the model outputs described in Piel et al. [21] and the births per year for 2010–2015 from the 2010 revision of the UN World Population Prospects [22].

b

CIs based on the interquartile range of the SCA frequency estimates and the low- and high-fertility variants for birth counts.

c

Calculated as the product between the median SCA frequency based on the model outputs described in Piel et al. [21], assuming constant allele frequencies over the study period and using the data on births per year for 2050–2055 from the 2010 revision of the UN World Population Prospects [22].

d

Total estimated newborns with SCA born between 2010 and 2050.

e

As defined at http://www.who.int/about/regions/en/index.html. AFRO, African Region; AMRO, Region of the Americas; EMRO, Eastern Mediterranean Region; EURO, European Region; SEARO, Southeast Asia Region; WPRO, Western Pacific Region.

f

As shown in Web Figure 8 of Web Appendix 2 of Piel et al. [21].