Projected number of newborns with SCA born in 2010 and 2050 for the three most affected countries (Nigeria, India, and the DRC), WHO regions, HbS regions, and worldwide.

<p>Complete data for all countries are presented in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001484#pmed.1001484.s002" target="_blank">Table S1</a>. Proportions per category are indicated for the predicted newborns with SCA. Relative changes are shown within parentheses.</p>a<p>Calculated as the product between the median SCA frequency based on the model outputs described in Piel et al. <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001484#pmed.1001484-Piel2" target="_blank">[21]</a> and the births per year for 2010–2015 from the 2010 revision of the UN World Population Prospects <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001484#pmed.1001484-United1" target="_blank">[22]</a>.</p>b<p>CIs based on the interquartile range of the SCA frequency estimates and the low- and high-fertility variants for birth counts.</p>c<p>Calculated as the product between the median SCA frequency based on the model outputs described in Piel et al. <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001484#pmed.1001484-Piel2" target="_blank">[21]</a>, assuming constant allele frequencies over the study period and using the data on births per year for 2050–2055 from the 2010 revision of the UN World Population Prospects <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001484#pmed.1001484-United1" target="_blank">[22]</a>.</p>d<p>Total estimated newborns with SCA born between 2010 and 2050.</p>e<p>As defined at <a href="http://www.who.int/about/regions/en/index.html" target="_blank">http://www.who.int/about/regions/en/index.html</a>. AFRO, African Region; AMRO, Region of the Americas; EMRO, Eastern Mediterranean Region; EURO, European Region; SEARO, Southeast Asia Region; WPRO, Western Pacific Region.</p>f<p>As shown in Web Figure 8 of Web Appendix 2 of Piel et al. <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001484#pmed.1001484-Piel2" target="_blank">[21]</a>.</p>