Prenatal LPS-induced deficits in spontaneous and miniature GABAergic activities in CA1 pyramidal cells.

(A) Spontaneous GABAergic activity recorded in CA1 pyramidal cells. The recapitulative graphs plot mean sIPSC frequency (left) and amplitude (right). The boxes define the median, 25^th and 75^th percentiles. The whiskers represent 10^th and 90^th percentiles. ^** p<0.01, Mann and Whitney rank sum test, N = 8 animals per group. (B) Miniature GABAergic activity recorded in CA1 pyramidal cells in the presence of TTX (100 nM). The recapitulative graphs plot mean mIPSC frequency (left) and amplitude (right). The boxes define the median, 25^th and 75^th percentiles. The whiskers represent the 10^th and 90^th percentiles. ^** p<0.01, Mann and Whitney rank sum test, N = 5 animals per group. Representative traces of GABAergic spontaneous activity (top) and GABAergic miniature activity (bottom) are shown in individual neurons from SAL (gray) and LPS (black) rats.