Prenatal LPS induced deficits in evoked inhibitory synaptic transmission in CA1 neurons.

(A) I/O relationships of eIPSCs were established for both SAL and LPS rats. The amplitudes of eIPSCs were normalized to the capacitance of the recorded cell and plotted against corresponding stimulus intensities. The duration of the stimuli was fixed at 100 µs. Hyperbolic fitting was performed on 127 experimental points obtained from SAL (open circles; N = 9) animals and 120 experimental points obtained from LPS (filled squares; N = 9) animals. Stippled zones represent the 95% Confidence Intervals of the curves. Each point represents the mean amplitude for the corresponding intensity of stimulation. For readability, SEMs were not represented. * p<0.05, for the comparison of LPS vs SAL animals, using two-way ANOVA followed by Holm-Sidak post-hoc analysis. (B) Representative traces of the eIPSCs recorded in SAL and LPS animals at two different intensities.