Predictions for Gp120 plotted on the protein structure including bound antibody.

<p>Each residue in the structure is colored from blue to red according to its <i>DiscoTope-2.0</i> score. Blue indicates low scores (predicted to be non-epitope residue) and red indicates high scores (predicted to be epitope residue). Yellow indicates possible glycosylation sites retrieved from UNIPROT accession number P04578 (<a href="" target="_blank"></a>). a) Gp120 surface representation and antibody cartoon representation. b) Gp120 and antibody cartoon representation. Note, the red alpha-1 helix, which is normally buried in the inner domain of Gp120 involved in Gp41∶Gp120 complex formation, is exposed in the crystal structure.</p>