Predicted two-dimensional H2AX phosphorylation patterns with and without the 3D spreading mechanism.

Example of XY projections of hit domains only (A) and of all phosphorylated domains obtained with the random expansion algorithm (B); the exposure to 1 Gy of X-rays photon radiation was simulated. The cell nucleus is represented in light grey in the background. The colour scale indicates the multiplicity of hit domains in the column of interest.