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Postprandial triglyceridemia, gut hormones, and gastric emptying in Dgat1+/− and Dgat1−/− mice.

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posted on 2013-02-19, 17:00 authored by Hua V. Lin, Dunlu Chen, Zhu Shen, Lei Zhu, Xuesong Ouyang, Aurawan Vongs, Yanqing Kan, John M. Levorse, Edward J. Kowalik Jr, Daphne M. Szeto, Xiaorui Yao, Jianying Xiao, Shirley Chen, Jinqi Liu, Marga Garcia-Calvo, Myung K. Shin, Shirly Pinto

4- to 5-month-old Dgat1+/−, Dgat1−/−, and wild type mice maintained on normal chow diet were fasted overnight, then p.o. dosed with (A–F) corn oil (100% lipid load, 8.14 kcal/ml) or (G–L) a mixed meal containing corn oil:Ensure-plus = 3∶17 v/v (19.4% lipid load, 2.48 kcal/ml) at 10 ml/kg body weight. At 2 h after meal challenge, plasma levels of (A) TG, (B, H) active GLP-1, (C, I) total GLP-1, (D, J) PYY, (E, K) GIP, and (F, L) stomach weight were measured. (G) In a separate cohort, plasma TG at 0, 1, 2, and 4h after 19.4% lipid load was determined. N = 8–12. *P<0.05, **P<0.01, ***P<0.001 vs. wild type. #P<0.05, ##P<0.01, ###P<0.001 Dgat1−/− vs. Dgat1+/−.

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