Figure 2.TIF (446.15 kB)
Polyamine pathway and metabolite changes after addition of toxic (500 µM) dose of eflornithine.
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posted on 2012-05-01, 01:14 authored by Isabel M. Vincent, Darren J. Creek, Karl Burgess, Debra J. Woods, Richard J. S. Burchmore, Michael P. BarrettX-axes indicate the time in hours since eflornithine addition. Y-axes indicate the raw abundance of each metabolite signal. Results show mean and standard deviation of 3 replicates.
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drug actiondrug targetsnifurtimoxTrypanosoma bruceiLC-MSarginase activityAfrican trypanosomiasisnon-targeted metabolomics approachbloodstream form trypanosomespolyamine pathway inhibitormetabolomic changesN-acetylated ornithinesynergise anti-trypanosomal activityEflornithinenucleotide metabolismcombinationactivationnon-targeted metabolomics-based approachUntargeted MetabolomicsDrug actionNifurtimoxmodepolyamine pathwayline treatmenttrinitrile metaboliteuntargeted metabolomics
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