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Phylogeny and Poisson-Fitter analysis of DG21 macaque env sequences.

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posted on 2014-10-31, 03:11 authored by Ratish Gambhira, Brandon F. Keele, John B. Schell, Meredith J. Hunter, Jason P. Dufour, David C. Montefiori, Haili Tang, John K. Rose, Nina Rose, Preston A. Marx

We analyzed 19 full-length envelope sequences from SIVsmE660 infected DG21 macaque. (A) phylogenetic comparison of DG21 env sequences to the generated consensus DG21 envelope sequence. (B) Highlighter plot exhibiting the nucleotide differences in DG21 env sequences compared to DG21 consensus sequence. (C) Poisson-Fitter plots of DG21 env sequences including APOBEC mutations. (D) Poisson-Fitter plots of DG21 env sequences excluding the APOBEC mutations.

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    vaccinatedSemliki Forest Virus Vector Immunized Rhesus Macaques IdentificationSingle genome amplificationSIVsmE 660 inoculumplasmacontrol influenza hemagglutinin proteinsfvSemliki forest virusvirus envelope lineagesenvelope sequencesV 4 loopinfectionrhesuhahivvsv4000 TCID 50. Single genome amplification

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