Table_1.xls (9.5 kB)
Pharmacokinetic parameters for allopregnanolone in both rabbit and mouse.
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posted on 2015-06-03, 03:12 authored by Ronald W. Irwin, Christine M. Solinsky, Carlos M. Loya, Francesco G. Salituro, Kathleen E. Rodgers, Gerhard Bauer, Michael A. Rogawski, Roberta Diaz BrintonLC-MS/MS measurements of allopregnanolone in plasma (top panel) or brain (bottom panel) after a single bolus dose (mg/kg body weight) by intravenous (IV), subcutaneous (SC), or transdermal (TD) administration.
Pharmacokinetic parameters for allopregnanolone in both rabbit and mouse.
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dosesedation behavior time courseregenerative treatment regimenoptimized complexation ratioallopregnanolone mouse plasma levelsdifferentiation transcription factor NeuroDpkcreballopregnanolone brain exposureAllopregnanolone Preclinical Acute Pharmacokinetic5 minIntravenous allopregnanolone transientlyNOAEL30 minpcnamtd
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