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Pathway analysis of tricuspid regurgitation velocity in sickle cell disease patients.

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posted on 2013-02-21, 03:46 authored by Xiaomei Niu, Mehdi Nouraie, Andrew Campbell, Sohail Rana, Caterina P. Minniti, Craig Sable, Deepika Darbari, Niti Dham, N. Scott Reading, Josef T. Prchal, Gregory J. Kato, Mark T. Gladwin, Oswaldo L. Castro, Victor R. Gordeuk

The numbers shown are standardized betas. Each of the arrows depicts a significant relationship (P<0.05). According to this analysis, higher hemolytic component was a direct predictor of increasing tricuspid regurgitation velocity and it also was associated with lower hemoglobin concentration and higher interleukin-6 concentration. Lower hemoglobin concentration was not a direct predictor of higher regurgitation velocity, but it was associated with higher VEGF concentration. Higher interleukin-6 concentration was a direct predictor of increasing tricuspid regurgitation velocity and it also was associated with higher VEGF and PDGF-BB concentrations. Higher PDGF-BB concentration was a direct predictor of increasing regurgitation velocity while higher VEGF concentration was a direct predictor of lower regurgitation velocity.

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