Oxygen consumption of isolated mitochondria in <i>Risp</i><sup>+/P224S</sup> mice.

2011-10-10T01:48:33Z (GMT) by Bryan G. Hughes Siegfried Hekimi
<p>Electron paths due to the combination of substrate and inhibitors used are indicated below each bar, as well as the sex (F for female, M for male). (<b>A</b>) Mitochondria isolated from liver of 3-month-old mice. All measurements were made in wild-type/heterozygote littermate pairs, and results are expressed as the effect of <i>Risp</i> heterozygosity relative to wild-type within each pair. (<b>B</b>) Mitochondria isolated from heart of 3-month-old mice. All measurements were made in wild type/heterozygote littermate pairs, and results are expressed as the effect of <i>Risp</i> heterozygosity relative to wild-type within each pair. (<b>C</b>) Mitochondria isolated from liver of 2-year-old mice. Due to the low probability of both members of wild-type/heterozygote littermate pairs surviving to this age, comparisons were made between the complete group of mice of each genotype. Actual values for (A) and (C) are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026116#pone.0026116.s002" target="_blank">Table S2</a>. Values for state 4 respiration and respiratory control ratio (state 3/state 4) are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026116#pone.0026116.s003" target="_blank">Table S3</a>. For all figures, sample sizes are shown superimposed on each bar. ‘*’ denotes p = 0.01 to 0.05 vs. 1.0 or wild-type control, ‘<sup>#</sup>’ p = 0.097 vs. 1.0.</p>