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Oocytes form a cluster distinct from bone marrow cells.

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posted on 2012-02-23, 01:53 authored by Yitzhak Reizel, Shalev Itzkovitz, Rivka Adar, Judith Elbaz, Adrian Jinich, Noa Chapal-Ilani, Yosef E. Maruvka, Nava Nevo, Zipora Marx, Inna Horovitz, Adam Wasserstrom, Avi Mayo, Irena Shur, Dafna Benayahu, Karl Skorecki, Eran Segal, Nava Dekel, Ehud Shapiro

Reconstructed cell lineage tree of mice in several ages, each showing that GV oocytes from large antral follicles (red) form a cluster that is distinct from cells of bone marrow origin (mesenchymal stem cells- yellow and lymphocytes-blue). Ovarian cumulus cells are in green. Shaded boxes denote subtrees that are statistically enriched for cells of a certain cell population, using a hyper-geometric enrichment test. Mouse names represent their age in days. Y axis is depth (number of divisions since the zygote). One cell in M278 was cropped for visual clarity.

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