Nrf2 activity in the brain area surrounding the blood clot in control group (n = 10), SAH group (n = 10), SAH+vehicle group (n = 10), and SAH+tBHQ group (n = 10).

Top, EMSA autoradiography of NF-κB DNA binding activity. Lane 1, control; lane 2, SAH; lane 3, SAH+vehicle; lane 4, SAH+tBHQ, respectively. Bottom, Levels of Nrf2 DNA binding activity quantified by computer-assisted densitometric scanning and expressed as arbitrary densitometric units (ADU). Nrf2 binding activity measured by EMSA was significantly higher than in the control group after SAH. tBHQ rendered Nrf2 activation significantly higher in the SAH+tBHQ group than in the SAH+vehicle group. *P<0.05 between control animals vs. SAH animals; ##P<0.01 between SAH+vehicle animals vs. SAH+tBHQ animals; nsP>0.05 between SAH animals vs. SAH+vehicle animals.