Figure_4.tif (4.3 MB)
Neutrophils infiltrate p120 null regions of the small intestine and colon.
figure
posted on 2013-02-20, 18:25 authored by Whitney G. Smalley-Freed, Andrey Efimov, Sarah P. Short, Peilin Jia, Zhongming Zhao, M. Kay Washington, Sylvie Robine, Robert J. Coffey, Albert B. Reynolds(A) p120 KO small intestine and colon sections were co-stained for p120 and neutrophils. Arrows and arrowheads indicate regions of p120 ablation. (B) Neutrophils were quantified in oil and tamoxifen-induced small intestine (p = .06) and colon (p = .0092) samples. (C) At the two-month time point, mice were gavaged with FITC-dextran, and serum levels of FITC-dextran were measured to test for an intestinal permeability defect. FITC-dextran levels were significantly higher (3.3-fold) in p120 KO mice (p = .03).
