Fig_4.tif (2.61 MB)
Network construction of co-expressed genes in relation to psychosis and autism spectrum disorders in 22q11DS.
figure
posted on 2015-07-22, 03:02 authored by Maria Jalbrzikowski, Maria T. Lazaro, Fuying Gao, Alden Huang, Carolyn Chow, Daniel H. Geschwind, Giovanni Coppola, Carrie E. BeardenA) Dendogram of modules identified through Weighted Gene Co-expression Analysis, created through linkage hierarchical clustering of genes. B) Module-Trait relationships for age, gender, psychotic disorder diagnosis, autism spectrum disorder diagnosis, and positive symptoms, as measured by the SIPs. Numbers shown represent Pearson correlations between the modules and traits. P-values are in parentheses. Numbers on the color bar refer to the strength of the correlation in the table (red = 1, green = -1).
History
Usage metrics
Categories
Keywords
idiopathic psychosisexpression changesantipsychotic medication userisk factors22 q 11.2 Deletion Syndromeresponse pathwaysWGCNA analyseshttranscriptional regulationidiopathic ASD.ConclusionThese findingsFunctional Pathways Relatedbrain tissue22 q 11DS patientsgeneidiopathic schizophrenia22 q 11DSperipheral blooddeletion characteristics22 q 11DS individualspathways dysregulated22 q 11DS carriersmoduleTranscriptome Profiling3 Mb deletiondata mining techniquesdeletion breakpointsdeGenomic Analysesphenotypic variationaCGH arrayspectrum disorderstranscriptional changes
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC