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NKT cell hypo-function in SIV-infected macaques.

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posted on 2013-02-19, 23:04 authored by Namita Rout, Justin Greene, Simon Yue, David O'Connor, R. Paul Johnson, James G. Else, Mark A. Exley, Amitinder Kaur

Amounts of IFN-γ, IL-2, IL-13, IL-10, IL-6, and TGF-β production in culture supernatants collected 24 h following in vitro stimulation of PBMC from SIV-negative and SIV-infected SM, RM and CM with (A) CD1d/αGC and (B) PMA/Ca ionomycin. Open bars denote mean values of cytokines secreted from SIV-negative animals (n = ≥6) and filled bars denote mean values of SIV-infected animals (n = ≥4) from each species. Error bars denote SEM. * P<0.05, ** P<0.01 Mann-Whitney U test.

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