MyD88 is involved in rapid inflammasome activation in response to <i>F. novicida</i> infection.

2011-06-16T01:32:33Z (GMT) by Crystal L. Jones David S. Weiss
<p>BMDM from wild-type and MyD88<sup>−/−</sup> C57BL/6 mice were infected with wild-type (WT) and <i>mglA</i> mutant strains of <i>F</i>. <i>novicida</i> (MglA) at the indicated MOIs. At 6.5 h post-infection, (A) death of the infected macrophages was measured by LDH release and (B) the concentration of IL-18 in the supernatants was quantified by ELISA. Data are representative of four independent experiments. Error bars represent the standard deviation of triplicate samples. ** p<0.0090.</p>