MyD88 is involved in rapid inflammasome activation in response to F. novicida infection.

BMDM from wild-type and MyD88^−/− C57BL/6 mice were infected with wild-type (WT) and mglA mutant strains of F. novicida (MglA) at the indicated MOIs. At 6.5 h post-infection, (A) death of the infected macrophages was measured by LDH release and (B) the concentration of IL-18 in the supernatants was quantified by ELISA. Data are representative of four independent experiments. Error bars represent the standard deviation of triplicate samples. ** p<0.0090.