Table_4.xls (9.5 kB)

Multivariate Cox proportional hazards analysis of genetic polymorphisms in relation to overall survival following breast cancer diagnosis, by ER status^*.

dataset

posted on 2008-04-25, 01:03 authored by Montserrat Garcia-Closas, Per Hall, Heli Nevanlinna, Karen Pooley, Jonathan Morrison, Douglas A. Richesson, Stig E. Bojesen, Børge G. Nordestgaard, Christen K. Axelsson, Jose I. Arias, Roger L. Milne, Gloria Ribas, Anna González-Neira, Javier Benítez, Pilar Zamora, Hiltrud Brauch, Christina Justenhoven, Ute Hamann, Yon-Dschun Ko, Thomas Bruening, Susanne Haas, Thilo Dörk, Peter Schürmann, Peter Hillemanns, Natalia Bogdanova, Michael Bremer, Johann Hinrich Karstens, Rainer Fagerholm, Kirsimari Aaltonen, Kristiina Aittomäki, Karl von Smitten, Carl Blomqvist, Arto Mannermaa, Matti Uusitupa, Matti Eskelinen, Maria Tengström, Veli-Matti Kosma, Vesa Kataja, Georgia Chenevix-Trench, Amanda B. Spurdle, Jonathan Beesley, Xiaoqing Chen, Australian Ovarian Cancer Management Group, The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Peter Devilee, Christi J. van Asperen, Catharina E. Jacobi, Rob A. E. M. Tollenaar, Petra E.A. Huijts, Jan G. M. Klijn, Jenny Chang-Claude, Silke Kropp, Tracy Slanger, Dieter Flesch-Janys, Elke Mutschelknauss, Ramona Salazar, Shan Wang-Gohrke, Fergus Couch, Ellen L. Goode, Janet E. Olson, Celine Vachon, Zachary S. Fredericksen, Graham G. Giles, Laura Baglietto, Gianluca Severi, John L. Hopper, Dallas R. English, Melissa C. Southey, Christopher A. Haiman, Brian E. Henderson, Laurence N. Kolonel, Loic Le Marchand, Daniel O. Stram, David J. Hunter, Susan E. Hankinson, David G. Cox, Rulla Tamimi, Peter Kraft, Mark E. Sherman, Stephen J. Chanock, Jolanta Lissowska, Louise A. Brinton, Beata Peplonska, Maartje J. Hooning, Han Meijers-Heijboer, J. Margriet Collee, Ans van den Ouweland, Andre G. Uitterlinden, Jianjun Liu, Low Yen Lin, Li Yuqing, Keith Humphreys, Kamila Czene, Angela Cox, Sabapathy P. Balasubramanian, Simon S. Cross, Malcolm W. R. Reed, Fiona Blows, Kristy Driver, Alison Dunning, Jonathan Tyrer, Bruce A. J. Ponder, Suleeporn Sangrajrang, Paul Brennan, James McKay, Fabrice Odefrey, Valerie Gabrieau, Alice Sigurdson, Michele Doody, Jeffrey P. Struewing, Bruce Alexander, Douglas F. Easton, Paul D. Pharoah

Analyses by ER status included data from 12 studies with information on vital status and ER status (CGPS, CNIO-BCS, HABCS, HEBCS, KBCP, kConFab, LUMCBCS, MCCS, PBCS, SASBCS, SBCS, SEARCH).

Per-allele hazard ratios (HR) and observed P values are adjusted for study. Allele changes are (common>rare based on frequencies in European populations): G>A for rs2981582; G>A for rs3803662; T>G for rs889312; A>G for rs13281615 and A>G for rs381798.

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Permutation adjusted P values.

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Per-allele hazard ratios (HR) and observed P values are adjusted for study, age at diagnosis (continuous), ER status and grade (continuous). Analyses limited to 11 studies with ER and grade information (CGPS, CNIO-BCS, HABCS, HEBCS, KBCP, LUMCBCS, MCCS, PBCS, SASBCS, SBCS, SEARCH).

The P values for the interaction between ER status and genotype adjusted for study, grade and age at diagnosis are: 0.60, 0.15, 0.29, 0.45, 0.38 for rs2981582, rs3803662, rs889312, rs13281615, rs381798, respectively.