Table_3.xls (9.5 kB)
Mouse transcripts most differentially dysregulated in the perifornical area of ataxin-3 transgenic animals versus control mice.
dataset
posted on 2009-01-22, 00:28 authored by Makoto Honda, Krister S. Eriksson, Shengwen Zhang, Susumu Tanaka, Ling Lin, Ahmad Salehi, Per Egil Hesla, Jan Maehlen, Stephanie E. Gaus, Masashi Yanagisawa, Takeshi Sakurai, Shahrad Taheri, Kuniaki Tsuchiya, Yutaka Honda, Emmanuel MignotThe perifornical area of 30 wild type and 30 ataxin-3 transgenic mice lacking hypocretin cells were punched (see Fig. S1) and samples pooled to perform microarray experiments. Hcrt-ataxin-3 transgenic mouse dysregulated genes are listed by order of transcript abundance (fold change). Most transcripts were decreased in Hcrt-ataxin-3 mice, some of which are known to be colocalized with hypocretin (NPTX2, dynorphin). Note that IGFBP3, which was identified by expression profiling using human hypothalami, was also decreased in this experiment.
