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Morphological abnormalities of the mutant NP at E15.5.

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posted on 2014-10-22, 03:18 authored by Christophe Merceron, Laura Mangiavini, Alexander Robling, Tremika LeShan Wilson, Amato J. Giaccia, Irving M. Shapiro, Ernestina Schipani, Makarand V. Risbud

A. H&E staining of E15.5 NP in control (Foxa2iCre;HIF-1αf/+) (a) and mutant (Foxa2iCre;HIF-1αf/f) (b) mice. Bar = 50 µm. B. Safranin O staining of E15.5 NP in control (HIF-1αf/f) (a) and mutant (Foxa2iCre;HIF-1αf/f) (b) specimens. Bar = 50 µm. C. In situ hybridization for aggrecan (a,b), collagen II (c,d), collagen X (e,f), and brachyury (g,h) mRNAs in control (HIF-1αf/f) (a,c,e,g) and mutant (Foxa2iCre;HIF-1αf/f) (b,d,f,h) NP at E15.5. Brightfield (a-f) and darkfield (g,h) pictures are shown. Bar = 50 µm.

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