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Model of sIL-2R elevation in B-cell lymphomas.

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posted on 13.11.2013 by Noriaki Yoshida, Miyo Oda, Yoshiaki Kuroda, Yuta Katayama, Yoshiko Okikawa, Taro Masunari, Megumu Fujiwara, Takashi Nishisaka, Naomi Sasaki, Yoshito Sadahira, Keichiro Mihara, Hideki Asaoku, Hirotaka Matsui, Masao Seto, Akiro Kimura, Koji Arihiro, Akira Sakai

MMP-9 released from tumor associated macrophages (especially CD68-positive) cleaves the IL-2R α chain on bystander T-cells and B-lymphoma cells, if they express CD25 (IL-2Rα). This mechanism may be involved in elevation of sIL-2R levels in patients with B-cell lymphomas.

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