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Model of Kif3a-mediated regulation of nephron number.

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posted on 2013-06-07, 01:17 authored by Lijun Chi, Alevtina Galtseva, Lin Chen, Rong Mo, Chi-chung Hui, Norman D. Rosenblum

A Kif3a control is required in both ureteric and metanephric mesenchyme cells for processes that control nephron number. In ureteric cells Kif3a acts in a GLI3R-dependent manner to control expression of Wnt11/Ret and ureteric branching. In metanephric mesenchyme cells, Kif3a functions to control cell survival and expression of Fgf8, which is required for maturation of nephrogenic progenitors. The lineage-specific functions of Kif3a in ureteric and metanephric mesenchyme cells converge to control nephron number.

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