Model of <i>Kif3a-</i>mediated regulation of nephron number.

<p>A <i>Kif3a</i> control is required in both ureteric and metanephric mesenchyme cells for processes that control nephron number. In ureteric cells <i>Kif3a</i> acts in a GLI3R-dependent manner to control expression of <i>Wnt11/Ret</i> and ureteric branching. In metanephric mesenchyme cells, <i>Kif3a</i> functions to control cell survival and expression of <i>Fgf8</i>, which is required for maturation of nephrogenic progenitors. The lineage-specific functions of <i>Kif3a</i> in ureteric and metanephric mesenchyme cells converge to control nephron number.</p>