Model clinical data comparison.

(Comparison between resistance at a flow rate of 0.17 L/s in the central airways model from CT data and the complete (parent) airways model with clinical data. Top row shows central airways, bottom row shows complete (parent) airways. Panels A & B show comparison of resistance with GINA Class, in both cases statistically significant (p < 0.001) differences were observed between resistances in healthy and severe (GINA 3–5) ashthmatics. Panels C & D show correlation between resistances and patient FEV1. In both cases moderate statistically significant correlations were observed (central: ρ = −0.52, p < 0.01, complete (parent): ρ = −0.64, p < 0.001). Panels E & F show correlation between resistances and FEV1/FVC. A mild statistically signifcant correlation was observed with airways resistance in the complete (parent) model: ρ = −0.56, p < 0.01). In all panels colour indicates patient GINA classification (Green: Healthy, Blue: GINA 1–2, Red: GINA 3–5). In panels C-F the solid line is a logarithmic regression (C-D) or linear regression (E-F) and the dashed lines are 95% confidence intervals for the regression. Regression coefficients were (C: Intercept (b) = -0.018, Slope (a) = 0.0035, D: b = 0.046, a = -0.038, E: b = 0.079, a = -0.041, F: b = 0.12, a = -0.12.