Microarray analysis of mutant and wildtype hypertrophic zones.

<p><i>(A)</i> Venn diagram depicting the relationship between probes indicating differential gene expression (fold difference ≥ 2.0, adjusted <i>p</i> value ≤ 0.01) following comparisons of <i>C/X</i> versus wildtype (<i>Wt</i>) (blue), <i>Xbp1</i><sup><i>CartΔEx2</i></sup> versus <i>Wt</i> (yellow), and <i>ColX</i><sup><i>N617K</i></sup> versus <i>Wt</i> (red), by whole genome microarray analysis of hypertrophic zone aRNA. <i>(B-D)</i> Ontological analysis of <i>(B)</i> all probes in cohort <i>i</i> in <i>(A)</i>, or those showing <i>(C)</i> up-regulation or <i>(D)</i> down-regulation, by Functional Annotation Clustering, using DAVID v6.7 software, and depicting representative gene ontology terms from each annotation cluster achieving an enrichment score (ES) ≥ 1.3.</p>