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Mean temperature rise (mean of post vaccination–pre-vaccination temperature) in rabbits after an IM injection of 100 μg protein containing dose of 1790GAHB (red circles) or equivalent volume of physiological saline (blue diamonds).

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posted on 2015-08-06, 03:49 authored by Christiane Gerke, Anna Maria Colucci, Carlo Giannelli, Silvia Sanzone, Claudia Giorgina Vitali, Luigi Sollai, Omar Rossi, Laura B. Martin, Jochen Auerbach, Vito Di Cioccio, Allan Saul

The vertical bars show the standard error of the mean. N = 12 for the 1790GAHB and 6 for the saline injected rabbits.

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    immunodominant O antigen componentlpsGAHBsonnei GMMA vaccinedose toxicology studyGeneralized ModulesMembrane Antigensstep filtration purificationrabbit pyrogenicity test29 ng proteinGMP pilot scaleEuropean Pharmacopoeia pyrogens methodShigella sonnei strainmonocyte activation testvirulence plasmid encodingadministrationShigella sonnei Vaccine

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