Mean plasma concentrations-versus-time plots of rifabutin (A), 25-<i>O</i>-desacetyl rifabutin (B), and rifabutin plus 25-<i>O</i>-desacetylrifabutin (C).

<p>Nine patients of Group I received 300 mg of rifabutin and 7 patients of Group II received 150 mg of rifabutin every other day with lopinavir/ritonavir-containing antiretroviral therapy. <i>Solid circles:</i> Group I, <i>open circles:</i> Group II. Data are mean ±1 standard errors. Dotted line in Figure C represents data of Group I during 0–24 hour for reference. RBT, rifabutin; PI/r, ritonavir-boosted protease inhibitor.</p>