Manhattan plot and Q-Q plot of genome-wide meta-analysis.

<p>(A) The Manhattan plot of the meta-analysis of Chinese, Malays and Indians. The minus log<sub>10</sub> of P-values (Y-axis) of inverse-variance meta-analysis across the 22 autosomal chromosomes after genomic control were plotted against the genomic coordinates. The horizontal line represents the genome-wide significant level of 5x10<sup>-8</sup>. (B) Q-Q plot of the observed P-values (Y-axis) against the expected P-values (X-axis). The diagonal line and its 95% confidence envelop were also plotted.</p>