MPV17 loss of function affects the purine branch of mitochondrial salvage pathway.
2016-01-18T15:33:16Z (GMT) by
<p>Representative immunoblot thymidine kinase 2 (TK2) in (<b>A</b>) control and MPV17-mutant fibroblasts in dividing and quiescent cells, and (<b>B</b>) in the liver of wild-type (WT) and knockout (KO) mice. (<b>C</b>) Steady state levels of adenylate kinase 2 and 3 (AK2 and AK3) and Deoxyguanosine Kinase (Dguok) in the liver of wild-type (WT) and knockout (KO) mice. The arrow indicates the Dguok isoform downregulated in KO mouse liver. The samples were from 2 month-old mice unless indicated. (<b>D</b>) AK2, AK3 and DGUOK steady state levels in control and MPV1<i>7</i> mutant fibroblasts in proliferating and quiescent cells. Vinculin, GAPDH, and Tom20 were used as loading control.</p>