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MMP1 metalloproteinase partly mimics the LIF effect.

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posted on 2016-01-18, 14:26 authored by Aya Abou Hammoud, Nina Kirstein, Virginie Mournetas, Anais Darracq, Sabine Broc, Camille Blanchard, Dana Zeineddine, Mohamad Mortada, Helene Boeuf

Cells were depleted from LIF for the indicated time and induced with 100 ng/mL of purified MMP1 as indicated. After 4 days, expression of the selected genes (A) Master genes, (B) Pluri genes and (C) Diff genes was analyzed by RT-qPCR. Graphs represent the average level of expression and SEM as depicted in Fig 2. One sample t-test was performed for each condition versus the +LIF sample: *p-value<0.05; **p-value<0.01, ***p-value<0.001; if not stated: not significant.

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