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MEM inhibits growth and viability of prostate cancer cells.
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posted on 2015-03-23, 03:52 authored by Maria Shabbir, Deeba N. Syed, Rahul K. Lall, Muhammad Rashid Khan, Hasan Mukhtara. Prostate cancer cells were treated with MEM for 24/48h, and cell viability was determined by MTT assay. Table shows the IC50 of CWR22Rν1, C4-2, PC-3 and DU145 at 24 and 48h. Mean ± SD of experiments performed in triplicate is shown. b. Dose-dependent effect of MEM on clonogenecity of CWR22Rν1 and C4-2 cells as detected by colony formation assay. Details are described in material methods. c. Effect of various fractions (n-hexane, ethyl acetate, n-butanol and aqueous) on viability of CWR22R ν1 cells, determined by MTT assay. *p<0.05 and **p<0.01 was considered statistically significant.
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prostate cancer cellsserum PSA levels reciprocatingprostate cancer cell culturesprostate cancer model systemMaytenus Royleanus Extracttime course analysisvivo modelparpantioxidant activitycaffeic acidEffective strategiesG 2 phase arrestintraperitoneal injectionCWR 22R cellsprostate cancer progressionMaytenus royleanuscarbohydrate moietiescell viabilityProstate cancerMEM fractionstumor growthmttarcell cyclecdk inhibitorsCell deathclonogenic survival assaysapoptotic proteinsstage prostate cancer
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