MDT-15 is required for defense against <i>P. aeruginosa</i> infection.

<p>A <i>P. aeruginosa</i> pathogenesis assay with wild-type N2, <i>mdt-15(tm2182)</i> mutant worms and <i>mdt-15(tm2182)</i> animals carrying <i>pmdt-15::mdt-15</i> (three independent lines <i>agEx116</i>, <i>agEx117</i> and <i>agEx118</i>) is shown. The difference in <i>P. aeruginosa</i> susceptibility between <i>mdt-15(tm2182)</i> animals and each of the three transgenic lines carrying <i>pmdt-15::mdt-15</i> is significant, as is the survival difference between N2 and <i>mdt-15(tm2182)</i> animals (<i>p</i><0.001). For sample sizes, see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004143#ppat.1004143.s009" target="_blank">Table S3</a>.</p>