Figure 7.TIF (228.62 kB)
Luciferase assay in NG108-15 cells using a HOXA13 wt and F344A mutant.
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posted on 2011-08-01, 00:14 authored by Yonghong Zhang, Christine A. Larsen, H. Scott Stadler, James B. AmesPercent luciferase activities (relative to wt control) are indicated on the y axis. HOXA13 wt or F344A (normalized to renilla and empty vector controls) are plotted on the x axis. Results are the mean percent values calculated from three independent experiments. Error bars represent the standard deviation of the three independent experiments.
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ATAA nucleotide sequence13DBDV 373 formtranscription factor protein11- mer DNA duplexgene366A N 370AHOXA 13 homeodomainNMRHOXA 13 dimerizationgroovetranscriptional activityExposed protein residuesAT-rich DNA sequencesN 370 side-chain forms hydrogen bondsmutation F 344Aprotein dimer interfacepyrimidine methyl groups373Gcontact
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