Lovastatin differentially affected the cell proliferation of normal <i>versus</i> cancer cells <i>in vitro</i>.

<p>The experimental protocol for the investigation of agents protecting normal cells against CDDP cytotoxicity is shown in (<b>A</b>). Cell cycle profiles of normal SDM104 (<b>B</b>) and (<b>C</b>), and ZL55 cancer cells (<b>D</b>) and (<b>E</b>) of control without treatment (<b>B</b>) and (<b>D</b>), or 24 hours treatment with 2 µM lovastatin (<b>C</b>) and (<b>E</b>) are shown (n = 3). Cells were exposed to 10 µM BrdU for one hour before harvesting for FACS analysis.</p>