Leptin counteracts the effect of hypoxia on hippocampal neurons.

<p><b>A.</b> Summarizing pie charts showing the percentage of electrodes potentiated (striped area), inhibited (black area) and unaltered (white area) by hypoxia, hypoxia+leptin and hypoxia+leptin+paxilline, either at 11 or 18 DIV. <b>B. Top.</b> Percentage of firing frequency reduction with respect to controls under the indicated conditions: hypoxia (black bars), leptin + hypoxia (light grey bars), leptin+hypoxia+paxilline (white bars). Leptin lowered the firing frequency reduction, either at 11 or 18 DIV (p<0.05 and p<0.01 respectively), while the addition of paxilline removed this effect.</p>