L-sel modulates atherosclerosis development.

Representative images of aortas stained with Oil-Red-O (ORO). Atherosclerotic lesion area is expressed as percentage of total aortic area. Compared to ApoE/ controls, there is an increased atherosclerotic burden in A) 12 week old ApoE/L-sel/ animals after 6 weeks of HCD (n = 11–15; *p<0.05); and B) 6 month old ApoE/L-sel/ animals after 6 months of a normal diet (n = 5–9; *p<0.05), but not C) 18 week old ApoE/L-sel/ animals after 12 weeks of HCD (n = 10–15; p = n.s.).