Figure_4.tif (261.39 kB)
Knockdown of Myo9b causes a Rho-dependent loss of bone resorptive capacity.
figure
posted on 2014-01-23, 02:45 authored by Brooke K. McMichael, Katharine F. Scherer, Nicole C. Franklin, Beth S. LeeA, siRNA-mediated knockdown of Myo9b diminishes resorptive capacity of osteoclasts in a Rho-dependent manner, as demonstrated by photomicrographs of resorption pits on ivory slices (top). Scale bar = 50 µm. Quantification of the surface area of each pit (pit area) and total resorbed surface area (total resorption) are shown graphically below. #: P<0.05; *: P<0.005; N.S. = not significant. B, Knockdown of Myo9b does not significantly affect osteoclast number or the ability of cells to form sealing zones on bone, as indicated by photomicrographs of phalloidin-labeled sealing zones (top) and enumeration of cell number and sealing zone number and size (bottom).
History
Usage metrics
Categories
Keywords
Molecular cell biologyCellular structurescytoskeletonCellular typesBone marrow cellsSignal transductionSignaling in cellular processesGTPase signalingcell adhesionAnatomy and physiologyMusculoskeletal systemboneGastroenterology and hepatologyCeliac diseaseInflammatory bowel diseasemyo9bcausesrho-dependentresorptive
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC