KV11.1 channel rectification and voltage dependence of inactivation.
figure
posted on 2015-09-16, 03:11 authored by Philip Juul Pedersen, Kirsten Brolin Thomsen, Emma Rie Olander, Frank Hauser, Maria de los Angeles Tejada, Kristian Lundgaard Poulsen, Soren Grubb, Rikke Buhl, Kirstine Calloe, Dan Arne Klaerke(A) Representative recordings of equine (n = 10) and human KV11.1 (n = 10) expressed in Xenopus laevis oocytes. (B) Fully activated current-voltage (I-V) relationship of the equine and human KV11.1 channels. The maximal conductance (G) of the tail currents was determined as the slope of a linear fit to maximal tail current amplitudes at potential between -120 to -90 mV. (C) Voltage dependence of rapid inactivation of equine and human Kv11.1. The rectification factor (R) at each potential was calculated using the current amplitudes plotted in Panel (B) (see Methods for calculation). Data were fitted with a Boltzmann equation.
