Intrastriatal bicuculline increases the amplitude and duration of striatal output.

A. Representative multiunitary response to cortical stimulation before, during and after delivering bicuculline into the striatum. The top trace corresponds to the rectified, smoothed and averaged action potential activity of 20 individual trials. Dotted line reflects 3 SD of multiunitary activity during 100 ms prior to stimulation onset (400 µA). Note the increase in the amplitude and duration of the response after bicuculline. Similar results were obtained for 300 µA cortical stimulation. B–D. Effect of bicuculline on the area (B), amplitude (C) and duration (D) of multiunitary action potential responses of 20 recording sites at the hot spot from 3 different experiments. * p<0.0001, Wilcoxon paired test. # p<0.0001 Student's paired t test.