Figure_4.tif (312.83 kB)
Interleukin-1 receptor signaling controls MyD88-dependent chemokine induction and neutrophil recruitment.
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posted on 2015-01-26, 02:47 authored by Anupam Jhingran, Shinji Kasahara, Kelly M. Shepardson, Beth A. Fallert Junecko, Lena J. Heung, Debra K. Kumasaka, Sue E. Knoblaugh, Xin Lin, Barbara I. Kazmierczak, Todd A. Reinhart, Robert A. Cramer, Tobias M. HohlMean (+SEM) of (A, C) BALF, (B, D) lung neutrophil recruitment and (E, G, I) BALF and (F, H, J) lung, (E, F) CXCL1, (G, H) CXCL2 and (I, J) CXCL5 levels in WT (black bars), IL-1R(−/−) (bars with diagonal stripes), IL-18R(−/−) (bars with crosshatch), TLR2(−/−) (dark grey bars), and TLR4(−/−) (light grey bars) mice 10 h p.i. with 3 × 107 conidia. Data are from 2 (A-D) or 1 (E-J) experiment(s) with 5–7 mice per genotype in each experiment. Graphs from a single experiment (out of three independent experiments) are shown for E, G and I.
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neutrophil chemokines CXCL 1neutrophil recruitmentfamily receptor signalsadaptor proteins triggersadaptor proteins CARD 9neutrophil lung traffickingCARD 9 actCXCL 2 reporter mouseMyD 88 expressionRespiratory Fungal Infection Aspergillus fumigatus formschemokine inductionlung neutrophil recruitmentMyD 88Exogenous CXCL 1 administrationadapter protein knockout miceCARD 9lung epithelial cellsradiosensitive hematopoietic cellsCARD 9 functionCXCL 2 productionphasesignal transduction pathwaysneutrophil conidial uptake
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