Fig_5.tif (954.22 kB)
Inhibitory effect of Sch B (25 and 50 mg/kg) treatment on inflammatory markers.
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posted on 2015-11-10, 03:32 authored by Vijayasree V. Giridharan, Rajarajan A. Thandavarayan, Somasundaram Arumugam, Makoto Mizuno, Hiroyuki Nawa, Kenji Suzuki, Kam M. Ko, Prasanna Krishnamurthy, Kenichi Watanabe, Tetsuya Konishi(a) Control (b) Aβ-infused (c) Aβ+SchB25 (d) Aβ+SchB50. Representative immunohistochemical detection of (A) COX-2 (B) iNOS-positive cells. The figures show quantification of (C) COX-2 (D) iNOS-positive cells. From each rat 5–6 coronal brain sections were selected and about 15 fields of the cerebral cortex were analyzed. Scale bar = 5μm (E) TNF-α, (F) IL-β, and (G) IL-6, mRNA expression in rat cerebral cortex quantified by densitometry. The results are given as the mean ± SD (n = 4). ** P < 0.01, compared with control group, and ##P < 0.01, #P < 0.05, significantly different from Aβ-infused rats.
