Inhibitory effect of Sch B (25 and 50 mg/kg) treatment on inflammatory markers.

<p>(a) Control (b) Aβ-infused (c) Aβ+SchB25 (d) Aβ+SchB50. Representative immunohistochemical detection of (A) COX-2 (B) iNOS-positive cells. The figures show quantification of (C) COX-2 (D) iNOS-positive cells. From each rat 5–6 coronal brain sections were selected and about 15 fields of the cerebral cortex were analyzed. Scale bar = 5μm (E) TNF-α, (F) IL-β, and (G) IL-6, mRNA expression in rat cerebral cortex quantified by densitometry. The results are given as the mean ± SD (n = 4). ** <i>P</i> < 0.01, compared with control group, and <sup>##</sup><i>P</i> < 0.01, <sup>#</sup><i>P</i> < 0.05, significantly different from Aβ-infused rats.</p>