Fig_7.tif (5.77 MB)
In vivo analysis of mice xenografted with MzChA-1 and MzChA-1_GR cells.
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posted on 2016-01-05, 14:56 authored by Takuya Sakamoto, Shogo Kobayashi, Daisaku Yamada, Hiroaki Nagano, Akira Tomokuni, Yoshito Tomimaru, Takehiro Noda, Kunihito Gotoh, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Shigeru Marubashi, Hidetoshi Eguchi, Yuichiro Doki, Masaki MoriNOD/SCID mice xenografted with MzChA-1 and MzChA-1_GR cells were employed as in vivo models. When the tumor volume was over 200 mm3, the mice were treated with the indicated drugs (GEM [125 mg/kg, once a week] and/or vorinostat [60 mg/kg, 5 consecutive days per week]). The prognostic value was evaluated by the Kaplan–Meier method and a log-rank test. (A) Survival curve for mice xenografted with MzChA-1 cells. (B) Survival curve for mice xenografted with MzChA-1_GR cells. (C) Immunohistochemistry for SMAD4 on the resected tumor specimens of the mice xenografted with MzChA-1_GR cells.
