<i>In vivo</i> analysis of mice xenografted with MzChA-1 and MzChA-1_GR cells.

<p>NOD/SCID mice xenografted with MzChA-1 and MzChA-1_GR cells were employed as <i>in vivo</i> models. When the tumor volume was over 200 mm<sup>3</sup>, the mice were treated with the indicated drugs (GEM [125 mg/kg, once a week] and/or vorinostat [60 mg/kg, 5 consecutive days per week]). The prognostic value was evaluated by the Kaplan–Meier method and a log-rank test. (A) Survival curve for mice xenografted with MzChA-1 cells. (B) Survival curve for mice xenografted with MzChA-1_GR cells. (C) Immunohistochemistry for SMAD4 on the resected tumor specimens of the mice xenografted with MzChA-1_GR cells.</p>