<i>In vitro</i> stress treatments change the pattern of MICA/B expression. A. Induction of TIA-1<sup>+</sup> granules in Caco-2 cells.

<p>Confocal microscopic analysis of Caco-2 cells treated during different periods of time with thapsigargin, sodium arsenite or fever-range temperature showing redistribution of TIA-1 (white) into stress granules. Nuclei (blue). (scan zoom 0,7, magnification 100×). <b>B.</b>- <b>Redistribution of MICA/B in treated Caco-2 cells</b>. Confocal microscopic analysis of Caco-2 cells treated during different periods of time with thapsigargin, sodium arsenite or fever-range temperature showing redistribution of MICA/B (red) in cytoplasmic aggregates. Nuclei (blue). (scan zoom 0,7, magnification 100×). <b>C.</b>- <b>Distribution of MICA/B and TIA-1 in Caco-2 treated cells.</b> Confocal microscopy of Caco-2 cells treated with thapsigargin (ER stress) or sodium arsenite (oxidative stress) for 1 hour, showing MICA/B (red) and TIA-1 (white) (magnification 100×). In both cases, MICA/B<sup>+</sup> structures were not associated to stress TIA-1<sup>+</sup> granules. (scan zoom 0,7, magnification 100×).</p>