In silico analyses revealed complex genomic architecture in regions of nonrecurrent rearrangement.

<p>(A) The ∼3 Mb surrounding the <i>PLP1</i> gene and (B) the ∼4 Mb surrounding the <i>MECP2</i> gene on the X chromosome contain numerous LCRs in various orientations <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000327#pgen.1000327-Lee3" target="_blank">[33]</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000327#pgen.1000327-Lee6" target="_blank">[106]</a>. LCRs are represented by the colored block arrows, and like LCR copies are designated by color and letter for a given sequence. Orientation is depicted by the direction of the block arrow.</p>