Impact of myriocin and antifungal drugs on phenoloxidase (PO) activity during <i>Candida albicans</i> pathogenesis.

<p>The <i>in vitro</i> PO activity of <i>G. mellonella</i> larval hemolymph was measured at 24 h during fungal pathogenesis and drug treatments. Significant decreases of PO activity were detected in the groups treated with AMPH and MYR+FLC (*p<0.001, n = 10) when compared with the controls. In addition, all the treatments in which <i>Candida</i> was present, a significant decrease of PO activity was observed when compared with the control groups (**p<0.001, n = 10). However larvae from MYR+CA group showed higher PO activity (§ p<0.05) when compared with CA group alone. Controls were uninjected (CT) or PBS injected larvae. The drug treatments and abbreviations are as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078905#pone-0078905-g001" target="_blank">Figure 1</a>. Error bars indicate standard errors. Each experiment was triplicated.</p>