Figure_2.tif (10.05 MB)
Immunohistochemistry of NeuN (A, B) and GFAP (C through F) in the OB.
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posted on 2013-12-31, 06:18 authored by Marina Hovakimyan, Anja Meyer, Jan Lukas, Jiankai Luo, Volker Gudziol, Thomas Hummel, Arndt Rolfs, Andreas Wree, Martin WittDistribution of NeuN-positive neuronal cells do not reveal any obvious differences between NPC1+/+ (A) and NPC1−/− mice (B) (67–70 d). There is a clear increase of GFAP expression, especially in the glomerular layer (Gl) in NPC1−/− animals (D) compared to NPC1+/+ (C). The area marked by the rectangles is enlarged in E and F, respectively, demonstrating the astrogliosis of the granular layer (Gr) in NPC1−/− mice. Counterstained with hematoxylin.
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Anatomy and physiologygeneticsHuman geneticsAutosomal recessiveNiemann-Pick diseasehistologyModel organismsAnimal modelsmouseMolecular cell biologyneuroscienceSensory systemsOlfactory systemClinical geneticsClinical research designAnimal models of diseaseDiagnostic medicinepathologyanatomical pathologyhistopathologyneuropathologyClinical pathologyneurologyNeurodegenerative diseasesneungfap
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