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Immune Alterations in Patients with Anti-Interferon-γ Autoantibodies

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posted on 2016-01-05, 14:56 authored by Nuttapol Chruewkamlow, Kodchakorn Mahasongkram, Supansa Pata, Romanee Chaiwarith, Parichart Salee, Khuanchai Supparatpinyo, Watchara Kasinrerk

Autoantibodies against interferon-gamma (IFN-γ) can cause immunodeficiency and are associated with various opportunistic infections. In the present study, we investigated other cellular immune parameters for a better understanding of the immunodeficiency condition in the patients. The numbers of WBC, monocytes and NK cells were increased in patients with anti-IFN-γ autoantibodies (AAbs). Upon TCR activation, T cell proliferation and IL-2 receptor of the patients remained intact. Nonetheless, the Th1 cytokine (IFN-γ and TNF-α) production was up-regulated. The production of Th2 (IL-4) and Th17 (IL-17) cytokines was unchanged. We suggest that, in addition to the presence of anti-IFN-γ autoantibodies, alterations in the cellular immune functions may also contribute to this immunodeficiency.

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